HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(Chloromethyl)-2-(trifluoromethyl)-1,3-thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol | HCID 20079604 | — |
| Product | 4-(Chloromethyl)-2-(trifluoromethyl)-1,3-thiazole | HCID 17750414 | 60.7% |
Reaction Steps
Thionyl chloride (4.89 g) was added to [2-(trifluoromethyl)thiazol-4-yl]methanol (512 mg) at room temperature, and the mixture was stirred for 3 hr. The reaction mixture was concentrated to give the title compound (342 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199963B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-c6f91f438ef24adf9d0a6d6db989878b |
| Source note | uspto-grants-2015_12 |