Sodium borohydride → HCID 86680621, compound

Participants

Reaction Steps

To a solution of 1-(5-(furan-3-yl)pyridin-2-yl)ethanone (0.2 g, 1.0752 mmol) in MeOH (10 ml) was added sodium borohydride (0.0795 g, 2.150 mmol) at 0° C., the reaction mixture warmed to room temperature and was stirred for 2 h. The reaction mixture was evaporated under reduced pressure to remove the methanol, diluted with water (15 mL), extracted with ethyl acetate (200 mL), dried over sodium sulphate and concentrated under reduced pressure to obtain crude product. The crude product was purified by Biotage Isolera® One column (using 20% ethyl acetate and hexane to give 1-(5-(furan-3-yl)pyridin-2-yl)ethanol as a colorless liquid (0.150 g, 73% yield). 1H NMR (400 MHz, DMSO-d6): δ 8.68 (s, 1H), 7.76 (t, 2H), 7.52 (s, 1H); 7.28 (t, 1H), 6.71 (s, 1H), 4.91 (d, 1H), 4.14-4.07 (m, 1H), 1.52 (d, 3H): LC-MS m/z calcd for [M+H]+ 189.08. found 190.0.

Provenance & Evidence