Sodium borohydride → HCID 86680624, compound

Participants

Reaction Steps

To a stirred solution of 1-(5-(4-nitrophenyl)pyridin-2-yl)ethanone (100 mg, 0.4 mmol) in THF (2 mL) and methanol (2 mL) was added NaBH4 (3 mg, 0.8 mmol) at rt and the reaction was stirred at rt for about 5 min. The reaction mixture was diluted with water (10 mL) and extracted with ethyl acetate (2×100 mL). The combined organic extracts were washed with brine solution (10 mL), organic layer was dried over Na2SO4 and concentrated under vacuum to obtain 1-(5-(4-nitrophenyl)pyridin-2-yl)ethanol as off white solid (100 mg, 100% yield). 1H NMR (400 MHz, DMSO-d6): δ 8.88 (d, 1H), 8.31 (d, 2H), 8.19 (dd, 1H), 8.01 (d, 2H), 7.64 (d, 1H), 5.43 (d, 1H), 4.78 (t, 1H), and 1.38 (t, 3H).

Provenance & Evidence