Triethylamine → HCID 86680633, compound

Participants

Reaction Steps

To solution of 2-(6-(1-hydroxypropyl)pyridin-3-yl)benzonitrile (0.05 g) in THF (3 mL) was added triethyl amine (0.042 g), the mixture was stirred for 5 minutes, and then methanesulfonyl chloride was added (0.47 g). The mixture was stirred at room temperature for 90 min. The reaction mixture was quenched with sodium bicarbonate and extracted with ethyl acetate. The organic extracts were dried over sodium sulphate, filtered and concentrated to obtain 1-(5-(2-cyanophenyl)pyridin-2-yl)propyl methanesulfonate (0.050 g, 71% yield), which was used directly in the next step.

Provenance & Evidence