4-Trifluoromethyl-1,2-phenylenediamine → HCID 11646459, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.70 g (3.0 mmol) 4-(3-chloropyridin-2-yl)benzoic acid in 25 g polyphosphoric acid was added 0.44 g (2.5 mmol) 4-trifluoromethylbenzene-1,2-diamine, followed by stirring at 150° C. for 20 hours. Then, the solution was cooled to room temperature, dissolved in distilled water and adjusted to pH 9 to form precipitates. These precipitates were purified using column chromatography (developing solvent: chloroform/methanol=30/1) to afford 0.61 g of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole (yield 65%).

Provenance & Evidence