4-Trifluoromethyl-1,2-phenylenediamine → HCID 11646459, compound

Participants

Reaction Steps

A solution of 0.70 g (3.0 mmol) 4-(3-chloropyridin-2-yl)benzoic acid and 0.44 g (2.5 mmol) 4-trifluoromethylbenzene-1,2-diamine in 10 mL polyphosphoric acid was stirred for 5 min and irradiated for 15 min with microwaves in a microwave reactor (Initiator Sixty, Biotage). After cooling to room temperature, 20 mL distilled water was added to the solution which was then adjusted to a neutral pH value with NaOH. The precipitates thus obtained was filtered and separated using column chromatography (developing solvent: chloroform/methanol=30/1) to produce 0.72 g of 2-[4-(3-chloropyridin-2-yl)phenyl]-6-trifluoromethyl-1H-benzoimidazole (yield 77%).

Provenance & Evidence