HCID 178454288, compound → HCID 178454287, compound

Participants

Reaction Steps

To a solution of 4-[4-(benzyloxy)-4-oxobutyl]phenyl 4-[N′,N″-bis(tert-butoxycarbonyl)carbamimidamido]benzoate (3.98 g) in tetrahydrofuran (40.0 mL) was added 10% palladium-carbon (398 mg), followed by stirring at room temperature for 3 hours under a hydrogen pressure of 3 atm. The reaction suspension was filtered through Celite, and then the filtrate was concentrated under reduced pressure to obtain 4-[4-({4-[N′,N″-bis(tert-butoxycarbonyl)carbamimidamido]benzoyl}oxy)phenyl]butanoic acid (3.30 g).

Provenance & Evidence