HCID 178454295, compound → HCID 178454294, compound

Participants

Reaction Steps

To a solution of 4-[2-(benzyloxy)-2-oxoethyl]-2-chlorophenyl 4-[N′,N″-bis(tert-butoxycarbonyl)carbamimidamido]benzoate (1.98 g) in tetrahydrofuran (27.1 mL) was added 10% palladium-carbon (196 mg), followed by stirring at room temperature for 1 hour at normal pressure under a hydrogen atmosphere. The reaction suspension was filtered through Celite, and then the filtrate was concentrated under reduced pressure to obtain [4-({4-[N′,N″-bis(tert-butoxycarbonyl)carbamimidamido]benzoyl}oxy)-3-chlorophenyl]acetic acid (1.78 g).

Provenance & Evidence