Acetic Acid → HCID 19361980, compound

HRID 1497503Notes

Reaction equation

HRID 1497503 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][C:3]=1CC#N.S(=O)(=O)(O)O.[C:19]([OH:22])(=[O:21])[CH3:20]>>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][C:3]=1[CH2:20][C:19]([OH:22])=[O:21]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 184250332,3-Dichloro-4-methoxybenzeneacetonitrile

Product 1

HCID 19361980HCID 19361980, compound

Conditions

Temperature
110 °C

Procedure

(2,3-Dichloro-4-methoxyphenyl)acetonitrile (770 mg) was dissolved in a 50% aqueous acetic acid solution (8.00 mL), and then concentrated sulfuric acid (4.00 mL) was added thereto, followed by stirring at 110° C. overnight. The reaction mixture was cooled to room temperature, then ice water was added to the mixture, and the resulting solid was collected by filtration and washed with water to obtain (2,3-dichloro-4-methoxyphenyl)acetic acid (737 mg).

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationthe resulting solid was collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-6fcbc12313fa421e9ce2b93103a4cae2
Source dataset
uspto-grants-2015_12
Patent number
US09199927B2

Reaction notes

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