Azobisisobutyronitrile → HCID 90282020, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of tert-butyl 2-methylquinoline-4-carboxylate (4.61 g) and carbon tetrachloride (50.0 mL) were added N-bromosuccinimide (3.71 g) and azobisisobutyronitrile (156 mg), followed by stirring at 90° C. for 5 hours. The reaction suspension was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain tert-butyl 2-(bromomethyl)quinoline-4-carboxylate (2.62 g).

Provenance & Evidence