HCID 90282021, compound → HCID 89451884, compound

Participants

Reaction Steps

A solution of methyl 2-({[3-(4-{[tert-butyl(dimethyl)silyl]oxy}-2-chlorophenyl)propanoyl]amino}methyl)benzoate (460 mg) in concentrated hydrochloric acid (10.0 mL) was stirred at 50° C. for 4 days. The reaction mixture was concentrated under reduced pressure, then to the residue was added chloroform-methanol, and the insoluble material was separated by filtration. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform-methanol) to obtain 2-({[3-(2-chloro-4-hydroxyphenyl)propanoyl]amino}methyl)benzoic acid (140 mg).

Provenance & Evidence