Water → HCID 131734212, compound

Participants

Reaction Steps

To a solution of tert-butyl [4-(benzyloxy)-2-chlorophenyl]carbamate (3.00 g) in N,N-dimethylformamide (45.0 mL) was added 55% sodium hydride (471 mg) under ice-cooling and a nitrogen flow, followed by stirring for 30 minutes under ice-cooling. Iodomethane (0.673 mL) was added thereto under ice-cooling, followed by stirring for 30 minutes. To the reaction mixture was added water, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain tert-butyl [4-(benzyloxy)-2-chlorophenyl]methylcarbamate (1.42 g).

Provenance & Evidence