Water → HCID 90281980, compound

Participants

Reaction Steps

To a solution of 2-chloro-N-methyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}aniline (1.00 g) in dichloromethane (20.0 mL) were added chloroacetyl chloride (0.415 mL) and triethylamine (0.872 mL) under ice-cooling, followed by stirring for 1 hour under ice-cooling. To the reaction mixture was added water, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, then dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain 2-chloro-N-(2-chloro-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)-N-methylacetamide (1.08 g).

Provenance & Evidence