Sodium Bicarbonate → HCID 69671539, compound

Participants

Reaction Conditions

Reaction Steps

A flask was charged with 6-(3-methoxy-4-nitrophenyl)-3-(2-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine (100 mg, 0.27 mmol), stannous chloride dihydrate (SnCl2, 300 mg, 1.35 mmol) and MeOH (10 mL). The mixture was stirred at 50° C. under Argon for 4 h. The pH of the mixture was adjusted to around 9 by progressively adding solid NaHCO3, and it was evaporated to afford the crude product. The crude product was purified by column chromatography on silica gel (petroleum ether:ethyl acetate=1:1) to give the title compound (28.5 mg, 31.2% yield) as yellow solids. 1H NMR (DMSO-d6): 7.99 (s, 1H), 7.87 (d, J=9.6 Hz, 1H), 7.75 (d, J=9.6 Hz, 1H), 7.67-7.61 (m, 2H), 7.32 (d, J=8.4 Hz, 1H), 7.19 (t, J=7.5 Hz, 1H), 7.07 (d, J=1.8 Hz, 1H), 7.02 (dd, J=8.1 and 1.8 Hz, 1H), 6.71 (d, J=8.1 Hz, 1H), 5.00 (s, 2H), 3.89 (s, 3H), 3.85 (s, 3H). MS: m/z 347.2 [M+H+].

Provenance & Evidence