(3-Boc-aminophenyl)boronic acid → HCID 69671140, compound

HRID 1497569Notes

Reaction equation

HRID 1497569 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[O:17][CH3:18])=[N:9][N:10]=2)[CH:7]=1.[C:19]([O:23][C:24]([NH:26][C:27]1[CH:28]=[C:29](B(O)O)[CH:30]=[CH:31][CH:32]=1)=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24]([NH:26][C:27]1[CH:32]=[C:31]([C:2]2[CH:3]=[CH:4][C:5]3[N:6]([C:8]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=4[O:17][CH3:18])=[N:9][N:10]=3)[CH:7]=2)[CH:30]=[CH:29][CH:28]=1)=[O:25])([CH3:22])([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 2773228(3-Boc-aminophenyl)boronic acidHCID 68900619HCID 68900619, compound

Product 1

HCID 69671140HCID 69671140, compound

Procedure

The title compound was prepared from 6-bromo-3-(2-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine and 3-(tert-butoxycarbonylamino)phenylboronic acid using a procedure similar to those described for the synthesis of Example 22, and was isolated as yellow solids (78 mg, 22.0% yield). MS: m/z 417.2 [M+H+].

Workup

  1. customthose described for the synthesis of Example 22

Sources & evidence

ORD record
ord-e741294f99ec4fb1940123f700cef9b6
Source dataset
uspto-grants-2015_12
Patent number
US09199983B2

Reaction notes

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