Hydrogen chloride-ethyl acetate → HCID 69671373, compound

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Reaction Steps

A mixture of 6-(3-(tert-butoxycarbonylamino)phenyl)-3-(2-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine (78 mg, 0.19 mmol) in HCl/ethyl acetate (2M, 20 mL) was stirred at room temperature for about 3 h. The mixture was concentrated under reduced pressure to give the crude compound. It was recrystallized in MeOH/ethyl acetate to give the title compound (9.8 mg, 15% yield) as yellow solids. 1H NMR (DMSO-d6): 8.36 (s, 1H), 8.16 (d, J=8.1 Hz, 1H), 8.05 (d, J=8.1 Hz, 1H), 7.78-7.60 (m, 5H), 7.49 (d, J=6.9 Hz, 1H), 7.37 (d, J=7.8 Hz, 1H), 7.23 (t, J=6.6 Hz, 1H), 3.92 (s, 3H). MS: m/z 317.2 [M+H+].

Provenance & Evidence