HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-Benzyl-3-methyl-5-nitroindazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzylhydrazine dihydrochloride | HCID 146540 | — |
| Reactant | 1-(2-Fluoro-5-nitrophenyl)ethan-1-one | HCID 2781067 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Benzyl-3-methyl-5-nitroindazole | HCID 21952162 | — |
Reaction Steps
2-Fluoro-5-nitroacetophenone (H. Sato et al, Bioorganic and Medicinal Chemistry Letters, 5(3), 233-236, 1995) (0.24 g) was treated with triethylamine (0.73 ml) and benzyl hydrazine dihydrochloride (0.255 g) in ethanol (20 ml) at reflux under N2 for 8 days. The mixture was cooled and the solid 1-benzyl-3-methyl-5-nitroindazole (0.16 g) was collected by filtration; m/z (M+1)+ 268.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199973B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-fc71c67302ac4967bf4e8cc2992161c2 |
| Source note | uspto-grants-2015_12 |