2-(Methylsulfonyl)ethanamine → HCID 9808378, compound

HRID 1497639Notes

Reaction equation

HRID 1497639 reaction equation
[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([F:34])=[C:24]([C:27]5[O:31][C:30]([CH:32]=O)=[CH:29][CH:28]=5)[CH:25]=4)[N:20]=[CH:19][N:18]=3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:35][S:36]([CH2:39][CH2:40][NH2:41])(=[O:38])=[O:37]>>[C:1]1([S:7]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([F:34])=[C:24]([C:27]5[O:31][C:30]([CH2:32][NH:41][CH2:40][CH2:39][S:36]([CH3:35])(=[O:38])=[O:37])=[CH:29][CH:28]=5)[CH:25]=4)[N:20]=[CH:19][N:18]=3)=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 43405612-(Methylsulfonyl)ethanamineHCID 21952209HCID 21952209, compound

Product 1

HCID 9808378HCID 9808378, compound

Procedure

Prepared according to Procedure D from 5-(4-(4-Phenylsulphonylphenylamino)-7-fluoro-quinazolin-6-yl)-furan-2-carbaldehyde (0.6 equiv) and 2-methanesulphonyl-ethylamine (1 equiv). 1H NMR (400 MHz, DMSO-d6) δ: 10.38 (s, 1H), 8.87 (d, 1H), 8.62 (s, 1H), 8.11 (d, 2H), 7.95 (m, 4H), 7.63 (m, 4H), 6.94 (m, 1H), 6.51 (d, 1H), 3.84 (s, 2H), 3.25 (m, 2H), 2.98 (s, 3H), 2.95 (m, 2H). ESI-MS m/z 579 (M−1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8b9e036c25c34a57a4fb31a57914eb16
Source dataset
uspto-grants-2015_12
Patent number
US09199973B2

Reaction notes

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