反应详情

To a solution of tert-butyl-4-carbamoylpiperidine-1-carboxylate (2.65 g, 11.62 mmol) in a DME/DCM 2:1 mixture (78 mL), Lawesson reagent (2.35 g, 5.81 mmol, 0.5 eq) was added and the mixture was stirred at r.t. overnight. The solvent was removed and the residue was taken up with ethyl acetate and washed with saturated aqueous K2CO3. The organic layer was separated, dried over Na2SO4 and concentrated to dryness. The residue was triturated with diethyl ether and dried to give 2.65 g (92%) of the title compound as a white solid.

1. customThe solvent was removed
2. washwashed with saturated aqueous K2CO3
3. customThe organic layer was separated
4. dry with materialdried over Na2SO4
5. concentrationconcentrated to dryness
6. customThe residue was triturated with diethyl ether
7. customdried