HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → Benzyl 4-carbamothioylpiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate | HCID 2776131 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Benzyl 4-carbamothioylpiperidine-1-carboxylate | HCID 18969329 | 37.8% |
Reaction Steps
Benzyl-4-carbamoylpiperidine-1-carboxylate (7.5 g, 38.6 mmol) was dissolved in THF (160 mL) and Lawesson's reagent (6.9 g, 17.1 mmol) was added. After 4 h the solvent was evaporated and the residue purified by flash-chromatography on silica gel (DCM-MeOH 95/5) affording 1.8 g (23%) of the title compound, crystallized from MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199979B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-619ea21751164cf6baca178aa6e0a9f0 |
| Source note | uspto-grants-2015_12 |