HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Oxane-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester | HCID 2773520 | — |
| Product | Oxane-4-carboxamide | HCID 13197203 | — |
Reaction Steps
A mixture of methyl tetrahydro-2H-pyran-4-carboxylate (7 g, 48.6 mmol) and 30% aqueous ammonia (20 mL) was stirred in a closed bottle at r.t. for 18 h. The ammonia excess was removed under reduced pressure and the residue was crystallized from ethanol affording 5.6 g (89%) of tetrahydro-2H-pyran-4-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199979B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-7770c77a67ef4c21888dbf84bf2e7137 |
| Source note | uspto-grants-2015_12 |