Lawesson's reagent → HCID 86704187, compound

Participants

Reaction Steps

1-cyclopropylpiperidine-4-carboxamide was suspended in dry THF (20 mL) and Lawesson's reagent (2.7 g, 6.67 mmol) was added. After refluxing for 6 h the solvent was concentrated under reduced pressure. The residue was dissolved in a ethyl acetate/MeOH mixture and washed with saturated aqueous NaHCO3. The aqueous phase was back-extracted with ethyl acetate and evaporated to dryness. The crude product was treated with ethanol and filtered. The white solid was dried under high vacuum affording 2.7 g of the title compound.

Provenance & Evidence