N-bromobutanimide → HCID 86704188, compound

Participants

Reaction Steps

150 mg (0.31 mmol) of N-{2,4-Difluoro-3-[2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-phenyl}-2,5-difluoro-benzenesulfonamide were suspended in 15 mL of dry DCM and 103 mg (0.62 mmol) of N-bromosuccinimide were added. The reaction was maintained at r.t. for 1 h then diluted with the same solvent and washed with aqueous NaHCO3. The organic layer was dried over Na2SO4 and evaporated. The residue was triturated with petroleum ether and filtered, to afford 128 mg (73%) of N-{3-[5-bromo-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-2,5-difluorobenzenesulfonamide.

Provenance & Evidence