Thiourea → HCID 86704191, compound

Participants

Reaction Conditions

Reaction Steps

21 mg (0.27 mmol) of thiourea were added to a solution of 122 mg (0.27 mmol) of N-[3-(bromoacetyl)-2-fluorophenyl]-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide in 5 mL of ethanol. The mixture was heated at 60° C. for 20 min in a microwave apparatus. The solvent was then removed, the residue taken up with DCM and washed with water. The organic layer was separated, dried over Na2SO4 and evaporated. The crude was purified by flash chromatography eluted with DCM-CH3OH 95/5, giving 92 mg (80%) of the title compound.

Provenance & Evidence