2-Bromo-1-(3-nitrophenyl)ethan-1-one → HCID 68285207, compound

Participants

Reaction Steps

A mixture of 2-bromo-1-(3-nitrophenyl)ethanone (245 mg, 1 mmol) and tetrahydro-2H-pyran-4-carbothioamide (144 mg, 1 mmol) is suspended in absolute ethanol (20 mL) and heated to reflux for 2 h. The solution is then cooled and evaporated to dryness. The crude is dissolved in DCM and washed twice with a solution of saturated sodium bicarbonate and once with water. The organic layer is dried up with sodium sulfate, filtered and evaporated to dryness to yield 285 mg of the title compound (98%).

Provenance & Evidence