Bromine → HCID 68285300, compound

Participants

Reaction Steps

To a solution of 4-(3-nitrophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazole (113 mg, 0.390 mmol) in acetic acid (10.5 mL), sodium acetate (71 mg, 0.866 mmol, 2.2 eq.) was added, and the mixture stirred for 30 min. To the solution so obtained, bromine was added dropwise and the reaction followed by HPLC up to completion (total Br2: 44 μL, 137 mg, 0.86 mmol, 2.2 eq). The solution was poured in 100 mL of 1M sodium hydroxide and extracted three times with ethyl acetate. The organic layer was washed with brine, dried up with sodium sulfate and evaporated to dryness to yield 5-bromo-4-(3-nitrophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazole (141 mg, 100%)

Provenance & Evidence