HCID 68285193, compound → HCID 68285229, compound

Participants

Reaction Steps

To a solution of 4-[4-(3-nitrophenyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-5-yl]pyridine in absolute ethanol (5 mL) and acetic acid (1 mL), zinc (300 mg) was added. The mixture was stirred and heated to reflux for 3 h. The mixture was dried up and treated with a small amount of 1 N HCl. After stirring for 1 h, the solution was brought to pH 14 using sodium hydroxide and extracted with DCM. The organic layer was dried with sodium sulfate and evaporated to driness. The solid material so obtained was purified by silica gel column chromatography eluting with ethyl acetate/hex/ammonium hydroxyde 8/2/0.1 yielding the title compound (52 mg, 59%).

Provenance & Evidence