HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-2-pyrazine-carboxylic acid → Ethyl 3-chloro-beta-oxo-2-pyrazinepropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-2-pyrazine-carboxylic acid | HCID 1501900 | — |
| Reactant | HCID 59864622 | HCID 59864622 | — |
| Reactant | HCID 178461627 | HCID 178461627 | — |
| Product | Ethyl 3-chloro-beta-oxo-2-pyrazinepropanoate | HCID 86725436 | 39.54% |
Reaction Steps
3-(3-Chloro-pyrazin-2-yl)-3-oxo-propionic acid ethyl ester (12) (2 g, 39.54%) was synthesized as a yellow liquid from 3.5 g of 3-chloro-pyrazine-2-carboxylic acid (11) and 5.64 g of ethyl potassium malonate (2) following the procedure described for 3-(3-fluoro-pyridin-2-yl)-3-oxo-propionic acid ethyl ester (3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199987B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-d1930d1553cb47b5a8ad72cb180a3cb1 |
| Source note | uspto-grants-2015_12 |