反应详情

温度

120 °C

To a suspension of 3-chloropicolinic acid (1.58 g, 10 mmol) in toluene (6 mL) was added an excess of thionyl chloride (9.52 g, 5.84 mL, 80.0 mmol) at room temperature under a nitrogen atmosphere. The resulting suspension was heated to 120° C. (oil bath temperature) and stirred for 20 h. Then, the solvent and excess of thionyl chloride were removed under vacuum and the residue was dissolved one more time in toluene and the solvent was removed again. The resulting residue was dried under high vacuum and used in the next step.

1. customThen, the solvent and excess of thionyl chloride were removed under vacuum
2. dissolutionthe residue was dissolved one more time in toluene
3. customthe solvent was removed again
4. customThe resulting residue was dried under high vacuum