Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 123869272 | HCID 123869272 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 131734225 | HCID 131734225 | — |
Reaction Steps
2-Methyl-propane-2-sulfinic acid (2-amino-5-bromo-phenyl)-phenyl-methyleneamide (70 g, 184 mol) is dissolved in 98:2 THF/H2O (800 mL) and was cooled to −50° C. Then NaBH4 (17.5 g, 462 mol) is added and the mixture is stirred at room temperature overnight. Then H2O is added and concentrated and extracted with EtOAc. The organic layer is concentrated to give product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09199988B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-c6c0af7bccc44d7a865932069032ae98 |
|---|
| Source note | uspto-grants-2015_12 |
|---|
