Water → HCID 117600048, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-Bromo-2-[[(1-methyl-4-piperidyl)-methylamino]-phenyl-methyl]aniline (0.96 g, 2.5 mmol), N,N′-carbonyldiimidazole (0.4 g, 2.5 mmol) and THF (20 ml) is stirred overnight at 60° C. Water is added and the mixture is extracted with EtOAc. The combined organic layers are dried over MgSO4 and concentrated in vacuo. The product is purified by RP HPLC.

Provenance & Evidence