Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3,5-Dimethylisoxazole-4-boronic acid | HCID 2734346 | — |
| Reactant | HCID 117600048 | HCID 117600048 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86273098 | HCID 86273098 | — |
Reaction Steps
To a mixture of 6-Bromo-3-[(1-methyl-4-piperidyl)methyl]-4-phenyl-1,4-dihydroquinazolin-2-one (100 mg, 0.24 mmol), 3,5-dimethylisoxazole-4-boronic acid (51 mg, 0.36 mmol), Na2CO3 (77 mg, 0.73 mmol) in dioxane (1.6 ml) with MeOH (0.4 ml) and water (0.2 ml) 1,1′-Bis(diphenylphosphino)ferrocene]dichloro-palladium(II) (17 mg, 0.02 mmol) is added. The mixture is stirred for 5 h at 80° C., concentrated in vacuo and the product purified by RP HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09199988B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-dcbb8c9fb4d04cd1b3ec0f7c75a4e54f |
|---|
| Source note | uspto-grants-2015_12 |
|---|
