Sodium Carbonate → HCID 86273350, compound

Participants

Reaction Steps

6-Bromo-4-phenyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one (150 mg, 0.493 mmol), 3,5-dimethyl-4-isoxazolylboronic acid (208.5 mg, 1.480 mmol), 1,1′-bis(diphenylphosphino)ferocene-palladium(II)dichloride dichloromethane complex (80.5 mg, 0.099 mmol) are added to a microwave vessel. A saturated acqueous solution of sodium carbonate (1 mL) and dimethoxyethane (2 mL) are added. The vessel is purged with argon for 10 min. The reaction mixture is heated in a microwave reactor for 90 minutes. The mixture is filtered and the filter cake is washed with dichloromethane. The volatiles are removed on in vacuo and the residue purified by reversed phase HPLC.

Provenance & Evidence