Sodium Pyrosulfite → HCID 117600739, compound

Participants

Reaction Steps

4-Bromo-2-[(4-methoxy-benzylamino)-phenyl-methyl]-phenol (0.30 g, 0.693 mmol) is slurried in acetonitrile (3 mL). An aqueous solution of ceric ammonium nitrate (1.15 g, 2.10 mmol) is slowly added dropwise at room temperature. The reaction mixture is shaken at room temperature for 2 hours. The mixture is poured into an aqueous solution of sodium pyrosulfite and left for half an hour. The aqueous phase is exhaustively extracted with ethyl acetate. The combined organic phases were dried over magnesium sulfate. After evaporated to in vacuo the residue is triturated with acetonitrile. The insoluble product is collected by filtration and dried. This provides the desired product.

Provenance & Evidence