Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3,5-Dimethylisoxazole-4-boronic acid | HCID 2734346 | — |
| Reactant | HCID 117600739 | HCID 117600739 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 117600617 | HCID 117600617 | — |
Reaction Steps
To a solution of 6-Bromo-4-phenyl-3,4-dihydro-benzo[e][1,3]oxazin-2-one (90 mg, 0.296 mmol) in 1,2-dimethoxyethane (3 mL) is added saturated Na2CO3 in water (3 mL), 3,5-dimethylisoxazole-4-boronic acid (90 mg, 0.607 mmol) and Pd(dppf)Cl2 (13.5 mg, 0.016 mml) The mixture is refluxed at 100° C. overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09199988B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-6dac08a6748142ba8b7d3aaf918fd244 |
|---|
| Source note | uspto-grants-2015_12 |
|---|
