N-Iodosuccinimide → HCID 117600656, compound

HRID 1497740Notes

Reaction equation

HRID 1497740 reaction equation
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1.[I:9]N1C(=O)CCC1=O>CC(O)=O>[I:9][C:7]1[C:3]([O:2][CH3:1])=[N:4][O:5][C:6]=1[CH3:8]

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 117685393-Methoxy-5-methylisoxazole

Product 1

HCID 117600656HCID 117600656, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 3-Methoxy-5-methyl-isoxazole (0.60 g, 5.0 mmol) in AcOH (15 mL) is added N-iodosuccinimide (1.10 g, 5.00 mmol) at 60° C. under nitrogen. Then the reaction mixture is stirred at 60° C. for 2 h. The mixture is concentrated in vacuo to give an oil. This oil is purified by column chromatography on silica gel to give the desired compound.

Workup

  1. concentrationThe mixture is concentrated in vacuo
  2. customto give an oil
  3. customThis oil is purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-5096fc4612af49eba601f5debdcd0d7f
Source dataset
uspto-grants-2015_12
Patent number
US09199988B2

Reaction notes

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