HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1497741Generated: October 30, 2026
1,2-Dimethoxyethane → HCID 86273822, compound
https://huagongshe.com/reaction/1497741
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 117600656 | HCID 117600656 | — |
| Reactant | HCID 123205558 | HCID 123205558 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86273822 | HCID 86273822 | — |
Reaction Steps
3-Methyl-4-phenyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-quinazolin-2-one (457 mg, 1.255 mmol), 4-Iodo-3-methoxy-5-methyl-isoxazole (150 mg, 0.628 mmol), potassium carbonate (173 mg, 1.255 mmol) and Pd(dppf)Cl2 (102.5 mg, 0.126 mmol) are added to a microwave vessel. Dimethoxyethane (0.1 mL) and water (0.1 mL) are added and the vessel flushed with argon. The mixture is heated in a microwave reactor at 120° C. for 3.5 hours. The reaction mixture is extracted with ethyl acetate from water. The organic phase is dried over Na2SO4 and the solvent is removed on a rotary evaporator. The residue is purified by reversed phase HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09199988B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-deb3e23ded1d484290e8d4b34fc01b9e |
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| Source note | uspto-grants-2015_12 |
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