2-Amino-6-methoxybenzoic Acid → (2-Amino-6-methoxyphenyl)methanol

Participants

Reaction Conditions

Reaction Steps

A mixture of LiAlH4 (6.826 g, 0.018 mol) and THF (300 mL) is stirred at 0° C. 2-amino-6-methoxy-benzoic acid (15 g, 0.09 mol) in THF (150 mL) is added to the reaction mixture. The mixture is stirred at room temperature for 3 h. The reaction is quenched by the addition of water. 250 mL of 10% NaOH solution is then added and extracted from water with ethylacetate to give the desired product.

Provenance & Evidence