(2-Amino-6-methoxyphenyl)methanol → 2-Amino-6-methoxybenzaldehyde

HRID 1497743Notes

Reaction equation

HRID 1497743 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[CH2:10][OH:11]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[CH:10]=[O:11]

Participants

4

Reactant 1

HCID 45090906(2-Amino-6-methoxyphenyl)methanol

Product 1

HCID 223267152-Amino-6-methoxybenzaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

A mixture of (2-Amino-6-methoxy-phenyl)-methanol (5.00 g, 0.033 mol) and manganese dioxide (13.7 g) in DCM (500 mL) iswas stirred at 25° C. for 24 h. The resulting solid is filtered off, washed with DCM to give the desired product.

Workup

  1. filtrationThe resulting solid is filtered off
  2. washwashed with DCM

Sources & evidence

ORD record
ord-58ce4eb7861e44e6906754ed6f2bdf6b
Source dataset
uspto-grants-2015_12
Patent number
US09199988B2

Reaction notes

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