4-(5-Tributylstannanyl-pyrazol-1-yl)-benzonitrile → N-[6-[2-(4-Cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide
Reaction equation
Br[C:2]1[C:3]([CH3:28])=[C:4]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=2)[C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:12](=[O:17])[C:13]([F:16])([F:15])[F:14])[N:10]=2)[CH:7]=1.C([Sn](CCCC)(CCCC)[C:34]1[N:38]([C:39]2[CH:46]=[CH:45][C:42]([C:43]#[N:44])=[CH:41][CH:40]=2)[N:37]=[CH:36][CH:35]=1)CCC>>[C:43]([C:42]1[CH:41]=[CH:40][C:39]([N:38]2[C:34]([C:2]3[C:3]([CH3:28])=[C:4]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=4)[C:5]4[N:6]([CH:8]=[C:9]([NH:11][C:12](=[O:17])[C:13]([F:16])([F:14])[F:15])[N:10]=4)[CH:7]=3)=[CH:35][CH:36]=[N:37]2)=[CH:46][CH:45]=1)#[N:44]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared from N-[6-bromo-7-methyl-8-(3-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide (Int. 5, 35 mg, 0.075 mmol) and 4-(5-tributylstannanyl-pyrazol-1-yl)-benzonitrile (Int. 3, 52 mg, 0.113 mmol) using a similar method to that used in Example 1 (Step 4), (6 mg).
Sources & evidence
- ORD record
- ord-4803dfbe30884c2aa14101aac952f6e6
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199984B2
Reaction notes
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