HRID1497764

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[c]1ccnn1-c1ccc(C#N)cc1

HCID86708088

未命名化合物

结构：Cc1c(Br)cn2nc(Cc3ccc(S(C)(=O)=O)cc3)nc2c1-c1cccc(C(F)(F)F)c1

HCID86708099

未命名化合物

PRODUCTS

生成物

结构：Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(Cc3ccc(S(C)(=O)=O)cc3)nc2c1-c1cccc(C(F)(F)F)c1

HCID73051427

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 6-bromo-2-(4-methanesulfonyl-benzyl)-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine (Int. 13, 50 mg, 0.095 mmol) and 4-(5-tributylstannanyl-pyrazol-1-yl)-benzonitrile (Int. 3, 100 mg, 0.218 mmol) using a similar method to that used in Example 1 (Step 4) (29 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-28adc3d00995481cae6aa4225aa94a9d
来源数据集: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09199984B2
来源说明: uspto-grants-2015_12

反应 SMILES

Br[C:2]1[C:3]([CH3:32])=[C:4]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=2)[C:5]2[N:6]([N:8]=[C:9]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:14][CH:13]=3)[N:10]=2)[CH:7]=1.C([Sn](CCCC)(CCCC)[C:38]1[N:42]([C:43]2[CH:50]=[CH:49][C:46]([C:47]#[N:48])=[CH:45][CH:44]=2)[N:41]=[CH:40][CH:39]=1)CCC>>[CH3:21][S:18]([C:15]1[CH:16]=[CH:17][C:12]([CH2:11][C:9]2[N:10]=[C:5]3[C:4]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:30])([F:31])[F:29])[CH:23]=4)=[C:3]([CH3:32])[C:2]([C:38]4[N:42]([C:43]5[CH:50]=[CH:49][C:46]([C:47]#[N:48])=[CH:45][CH:44]=5)[N:41]=[CH:40][CH:39]=4)=[CH:7][N:6]3[N:8]=2)=[CH:13][CH:14]=1)(=[O:20])=[O:19]