2-chloro-N-methylacetamide → 2-[6-[2-(4-Cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-2-yl]-N-methyl-acetamide
Reaction equation
[CH3:1][C:2]1[C:7]([C:8]2[N:12]([C:13]3[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=3)[N:11]=[CH:10][CH:9]=2)=[CH:6][N:5]2[C:21](=[O:24])[NH:22][N:23]=[C:4]2[C:3]=1[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=1.Cl[CH2:36][C:37]([NH:39][CH3:40])=[O:38]>>[C:17]([C:16]1[CH:19]=[CH:20][C:13]([N:12]2[C:8]([C:7]3[C:2]([CH3:1])=[C:3]([C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:32])[F:33])[CH:26]=4)[C:4]4[N:5]([C:21](=[O:24])[N:22]([CH2:36][C:37]([NH:39][CH3:40])=[O:38])[N:23]=4)[CH:6]=3)=[CH:9][CH:10]=[N:11]2)=[CH:14][CH:15]=1)#[N:18]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared from 4-{5-[7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile (Ex. 9, 55 mg. 0.12 mmol) and 2-chloro-N-methylacetamide (19 μL, 0.18 mmol), using a similar method to that used in Example 11 (25 mg).
Sources & evidence
- ORD record
- ord-aaf79fbb0d204c63bd0bfd432bcf5b1d
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199984B2
Reaction notes
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