1-Bromo-3-methanesulfonylpropane → 4-{5-[2-(3-Methanesulfonyl-propyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile
Reaction equation
[CH3:1][C:2]1[C:7]([C:8]2[N:12]([C:13]3[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=3)[N:11]=[CH:10][CH:9]=2)=[CH:6][N:5]2[C:21](=[O:24])[NH:22][N:23]=[C:4]2[C:3]=1[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=1.Br[CH2:36][CH2:37][CH2:38][S:39]([CH3:42])(=[O:41])=[O:40]>>[CH3:42][S:39]([CH2:38][CH2:37][CH2:36][N:22]1[C:21](=[O:24])[N:5]2[CH:6]=[C:7]([C:8]3[N:12]([C:13]4[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=4)[N:11]=[CH:10][CH:9]=3)[C:2]([CH3:1])=[C:3]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:32])[F:33])[CH:26]=3)[C:4]2=[N:23]1)(=[O:41])=[O:40]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared from 4-{5-[7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile (Ex. 9, 70 mg. 0.152 mmol) and 1-bromo-3-methanesulfonyl-propane (53 mg, 0.264 mmol) using a similar method to that employed for Example 11 (27 mg).
Sources & evidence
- ORD record
- ord-425129c64ec749d58c6ad7987e9dc324
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199984B2
Reaction notes
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