HRID1497778

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6328

Methyl iodide

CH3I

结构：Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NC(=O)CN3CCN(C)CC3)nc2c1-c1cccc(C(F)(F)F)c1

HCID73051584

未命名化合物

PRODUCTS

生成物

结构：Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NC(=O)CN3CC[N+](C)(C)CC3)nc2c1-c1cccc(C(F)(F)F)c1.[I-]

HCID73051585

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from N-[6-[2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-2-(4-methyl-piperazin-1-yl)-acetamide (Ex. 18, 130 mg, 0.22 mmol) and MeI (27 μL, 0.880 mmol.) using a similar method to that employed for Example 15 (105 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9a31c3fbc9914f1eb1b313201d6a8f04
来源数据集: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09199984B2
来源说明: uspto-grants-2015_12

反应 SMILES

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([C:14]3[C:15]([CH3:44])=[C:16]([C:34]4[CH:39]=[CH:38][CH:37]=[C:36]([C:40]([F:43])([F:42])[F:41])[CH:35]=4)[C:17]4[N:18]([N:20]=[C:21]([NH:23][C:24](=[O:33])[CH2:25][N:26]5[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]5)[N:22]=4)[CH:19]=3)=[CH:12][CH:11]=[N:10]2)=[CH:5][CH:4]=1)#[N:2].[CH3:45][I:46]>>[I-:46].[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([C:14]3[C:15]([CH3:44])=[C:16]([C:34]4[CH:39]=[CH:38][CH:37]=[C:36]([C:40]([F:42])([F:43])[F:41])[CH:35]=4)[C:17]4[N:18]([N:20]=[C:21]([NH:23][C:24]([CH2:25][N:26]5[CH2:31][CH2:30][N+:29]([CH3:45])([CH3:32])[CH2:28][CH2:27]5)=[O:33])[N:22]=4)[CH:19]=3)=[CH:12][CH:11]=[N:10]2)=[CH:5][CH:4]=1)#[N:2]