Thiomorpholine 1,1-dioxide → N-[6-[1-(4-Cyano-phenyl)-1H-pyrazol-5-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-2-(1,1-dioxothiomorpholin-4-yl)-acetamide

Participants

Reaction Steps

The title compound was prepared from 2-chloro-N-[6-[2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide (Int. 17, 50 mg, 0.0934 mmol) and thiomorpholine 1,1-dioxide (20 mg, 0.148 mmol) using a similar method to that employed for Example 18, Step 2 (10 mg).

Provenance & Evidence