HRID1497783

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7818

1,4-Dimethylpiperazine

C6H14N2

结构：Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NC(=O)CCl)nc2c1-c1cccc(C(F)(F)F)c1

HCID86708103

未命名化合物

PRODUCTS

生成物

结构：Cc1c(-c2ccnn2-c2ccc(C#N)cc2)cn2nc(NC(=O)C[N+]3(C)CCN(C)CC3)nc2c1-c1cccc(C(F)(F)F)c1.[Cl-]

HCID73052077

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 2-chloro-N-[6-[2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide (Int. 17, 80 mg, 0.149 mmol) and 1,4-dimethyl-piperazine (34 mg, 0.298 mmol) using a similar method to that employed for Example 18 (step 2) (38 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-57c843ad6fbf4b6dbda77436f5cd70ab
来源数据集: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09199984B2
来源说明: uspto-grants-2015_12

反应 SMILES

[Cl:1][CH2:2][C:3]([NH:5][C:6]1[N:38]=[C:9]2[C:10]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=3)=[C:11]([CH3:27])[C:12]([C:14]3[N:15]([C:19]4[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=4)[N:16]=[CH:17][CH:18]=3)=[CH:13][N:8]2[N:7]=1)=[O:4].[CH3:39][N:40]1[CH2:45][CH2:44][N:43]([CH3:46])[CH2:42][CH2:41]1>>[Cl-:1].[C:25]([C:22]1[CH:23]=[CH:24][C:19]([N:15]2[C:14]([C:12]3[C:11]([CH3:27])=[C:10]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=4)[C:9]4[N:8]([N:7]=[C:6]([NH:5][C:3]([CH2:2][N+:40]5([CH3:39])[CH2:45][CH2:44][N:43]([CH3:46])[CH2:42][CH2:41]5)=[O:4])[N:38]=4)[CH:13]=3)=[CH:18][CH:17]=[N:16]2)=[CH:20][CH:21]=1)#[N:26]