HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Dimethylaminobutylamine → 4-{5-[2-(4-Dimethylamino-butylamino)-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Dimethylaminobutylamine | HCID 77063 | — |
| Reactant | 4-{5-[2-(3-Dimethylamino-propylamino)-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile | HCID 73051920 | — |
| Reactant | 4-{5-[2-Chloro-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile | HCID 86708105 | — |
| Product | 4-{5-[2-(4-Dimethylamino-butylamino)-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile | HCID 73051922 | — |
Reaction Steps
The title compound was prepared from 4-{5-[2-chloro-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile (Int. 19, 93 mg, 0.19 mmol) and N,N-dimethyl-butane-1,4-diamine (1.0 mL) using a similar method to that used in Example 28 (47 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199984B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-77b134ffe153484d8d78a84007940b3e |
| Source note | uspto-grants-2015_12 |