Hydrazine hydrate (1:1) → 4-Hydrazino-3-methanesulfonyl-benzonitrile

Participants

Reaction Steps

A suspension of 4-fluoro-3-(methylsulfonyl)benzonitrile (1.96 g, 9.83 mmol) in IMS (30 mL) was treated with hydrazine monohydrate (1.19 mL, 24.8 mmol) and then heated at reflux for 1 hr. The reaction mixture was cooled then filtered and the solid residue was collected and dried in vacuo to afford the title compound as a cream solid (1.64 g).

Provenance & Evidence