Ethyl Acetate → N-[6-(3-Dimethylamino-acryloyl)-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide

HRID 1497802ノート

反応式

HRID 1497802 の反応式
[C:1]([C:4]1[C:5]([CH3:27])=[C:6]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[C:7]2[N:8]([N:10]=[C:11]([NH:13][C:14](=[O:16])[CH3:15])[N:12]=2)[CH:9]=1)(=[O:3])[CH3:2].CO[CH:30](OC)[N:31]([CH3:33])[CH3:32].CCOC(C)=O>C1(C)C=CC=CC=1>[CH3:30][N:31]([CH3:33])[CH:32]=[CH:2][C:1]([C:4]1[C:5]([CH3:27])=[C:6]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[C:7]2[N:8]([N:10]=[C:11]([NH:13][C:14](=[O:16])[CH3:15])[N:12]=2)[CH:9]=1)=[O:3]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 78373Dimethylformamide dimethyl acetalHCID 86708111N-[6-Acetyl-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide

生成物 1

HCID 86708112N-[6-(3-Dimethylamino-acryloyl)-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

A suspension of N-[6-acetyl-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-acetamide (Int. 24, 732 mg, 1.947 mmol) and dimethylformamide dimethylacetal (4 mL) in toluene (10 mL) was heated at 100° C. for 2 hrs. The reaction mixture was cooled then EtOAc (50 mL) was added and the resultant precipitate was collected by filtration to afford the title compound as a white solid (508 mg).

後処理

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe resultant precipitate was collected by filtration

出典と根拠

ORDレコード
ord-390dda379c0749d39d178a19b3f17299
出典データセット
uspto-grants-2015_12
特許番号
US09199984B2

反応ノート

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