3-(Methylthio)propanoic acid → N-[6-[2-(4-Cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-methylsulfanyl-propionamide

Participants

Reaction Steps

The title compound was prepared from 4-{5-[2-amino-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-pyrazol-1-yl}-benzonitrile (Ex. 1, 100 mg, 0.218 mmol) and 3-methylsulfanyl-propionic acid (45 μL, 0.436 mmol) by a similar method to that employed in Example 16 (130 mg).

Provenance & Evidence